San Diego State University

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Michael J. Buono


Mike Buono

Michael J. Buono, Professor

Phone: (619) 594-6823
Office: ENS 314


  • Ph.D., University of Arizona, Animal Physiology (1982)

Biographical Statement

I consider myself a Systemic Human Physiologist, the last of a dying breed! Specifically, I use exercise and environmental perturbations to explain physiological control systems in humans. Naturally, most of this research is quite applied in nature. Over the last 25 years I have published papers (n ~ 100) in such places as the American Journal of Physiology, European Journal of Physiology, Journal of Applied Physiology, Journal of Thermal Biology, and Physical Therapy just to name a few.

Selected Publications

Hodge, D, Jones, D., Martinez, R., and Buono, M.J. (2013) Time Course of the Attenuation of Sympathetic Nervous Activity during Active Heat Acclimation.   Autonomic Neuroscience: Basic and Clinical, 177:101-103

Wing, D, Prausnitz, MR, and Buono, MJ. “Skin Pretreatment with Microneedles Prior to Pilocarpine Iontophoresis Increases Sweat Production.”  Clinical Physiology and Functional Imaging, 33: 436-440, 2013

Martinez, R, Jones, D., Hodge, D., and Buono, M.J. “Blocking the Beta-adrenergic System does not affect Sweat Gland Function during Heat Acclimation.”  Autonomic Neuroscience: Basic and Clinical, 169:113-115, 2012

Buono, M.J., Tabor, B., and White, A. “Local Beta-Adrenergic Receptor Blockade does not  Affect Sweating During Exercise.”  American Journal of Physiology, 300: R1148-1151, 2011.

Buono, M.J., Avila,S., Garnero, L., Fader, L., and Kolkhorst, F. (2011) The Effect of Heat Acclimation on Maximal Urine Osmolality in Human. Journal of Thermal Biology, 36: 157-159.

Buono, M.J., Numan, T.R., Claros, R.M., Brodine, S.K., Kolkhorst, F.W. (2009), Is active sweating during heat acclimation required for improvements in peripheral sweat gland function? American Journal of Physiology 297: R1082–R1085.

Buono, M.J., Martha, S. and Heaney, J. (2009), Peripheral Sweat Gland Function is Improved with Humid Heat Acclimation. Journal of Thermal Biology, 34:127-130.

Buono, M.J., Claros, R., Deboer, T., and Wong, J. (2008), Na+ Secretion Rate Increases Proportionally More than the Na+ Reabsorption Rate with Increases in Sweat Rate. Journal of Applied Physiology, 105: 1044-1048

Buono, M. J., Ball K. D., and Kolkhorst, F. W. (2007), Sodium Ion Concentration vs. Sweat Rate Relationship in Humans. Journal of Applied Physiology, 103: 990-994

Buono, M. J. , P. W. Miller, C. Hom, R. S. Pozos, and F. W. Kolkhorst. (2005), Skin Blood Flow Affects In Vivo Near-Infrared Spectroscopy Measurements in Human Skeletal Muscle. Japanese Journal of Physiology. 55: 241-244.

Buono, M. J., S. Burke, S. Endemann, H. Graham, C. Gressard, and L. Griswold. (2004) The Effect of Ambient Air Temperature on Whole-Body Bioelectrical Impedance. Physiological Measurement. 25: 119-123.

Buono, M. J. and L. S. Verity. (2004) Cholinergic Induced Sweat Rate During Hypo- and Hyperglycemia. Clinical Kinesiology. 58: 11-12.

Kolkhorst, F., R. Rezende, S. Levy, and M. J. Buono. (2004) Effects of Sodium Bicarbonate on VO2 Kinetics during Heavy Exercise. Medicine and Science in Sports and Exercise. 36: 1895-1899.

Austin, K., J. Hansbrough, C. Dore, J. Noordenbos, and M. J. Buono. (2003) Thermoregulation in Burn Patients during Exercise. Journal of Burn Care and Rehabilitation. 24: 9-14.

DiPasquale, D.M., M.J. Buono, and F.W. Kolkhorst. (2003) Effect of skin temperature on cholinergic sensitivity to the human eccrine sweat gland. Japanese Journal of Physiology. 53: 427-430.

Buono, M. J. and C. J. Maupin. (2003) Relationship Between Sweat Gland Recruitment and Esophageal Temperature during Exercise-Induced Hyperthermia.  Journal of Thermal Biology. 28: 381-384.

DiPasquale, D., F. Kolkhorst, J. Nichols, and M. J. Buono. (2002) Effect of Acute Normobaric Hypoxia on Peripheral Sweat Rate.  High Altitude Medicine and Biology. 3: 289-293.

Yaggie, J. A., T. J. Niemi and M. J. Buono. (2002), Adaptive Sweat Gland Response After Spinal Cord Injury, Archives of Physical Medicine and Rehabilitation, 83, 802-805.

Buono, M. J. and F. Kolkhorst. (2001), Estimating ATP Resynthesis during a Marathon Run: A Method to Introduce Metabolism, Advances in Physiology Education. 25, 70-71.

Buono, M. J. (2000), Limb vs. Trunk Sweat Gland Recruitment Patterns During Exercise in Humans, Journal of Thermal Biology, 25, 263-266.

Buono, M. J. and A. Wall. (2000), Effect of Hypohydration on Core Temperature During Exercise in Temperate and Hot Environments, European Journal of Physiology, 440, 476-480.

Buono, M. J. (1999), Sweat Ethanol Concentrations are Highly Correlated with Co-existing Blood Values in Humans, Experimental Physiology, 84, 401-404.

Buono, M. J., J. Heaney and K. Canine. (1998), Acclimation to Humid Heat Lowers Resting Core Temperature, American Journal of Physiology, 274, R1295-R1299.

Martin, J. G. and M. J. Buono. (1997), Oral Contraceptives Elevate Core Temperature and Heart Rate during Exercise in the Heat, Clinical Physiology, 17, 123-126.

Heaney, J. H., Buono, M. J., Pimental, N. A. and J. A. Hodgdon. (1996), The Effects of Exercise and Gender on Heat Tolerance Time During Prolonged Heat Exposure, Environmental Ergonomics; Recent Progress and New Frontiers, Editors: Shapiro, Y., Moran, D. S., and Y. Epstein, Pages 93-96.

Buono, M. J., Heaney, J. H., Cline, J. A. and S.A. Leichliter. (1996), Cardiovascular Drift Can Occur Without a Concomitant Increase in Skin Blood Flow, Experimental Biology Online. 1,7.

Buono, M. J. and R. Maly. (1996), Augmented Hyperventilation via Normoxic Helium Breathing Does Not Prevent Exercise-Induced Hypoxemia, Canadian Journal of Applied Physiology, 21, 264-270.

Buono, M. J., Hodgdon, J., Sjoholm, N. and T. Borin. (1996), Validity and Reliability of a Timed 5 Kilometer Cycle Ergometer Ride to Predict Maximum Oxygen Uptake, Physiological Measurement, 17, 313-317.

Robinson, S. E., and M. Buono. (1995), Effect of Continuous-Wave Ultrasound on Blood Flow in Skeletal Muscle, Physical Therapy, 75,145-150.

Buono, M. J., and K. P. Connolly. (1992), Sweat Gland Recruitment Versus Glandular Output During Exercise, Journal of Thermal Biology, 4/5,267-270.C. S.

Buono, M. J., McKenzie, B. K., and F. W. Kasch. (1991), Effects of Aging and Physical Training on the Peripheral Sweat Production of the Human Eccrine Sweat Gland, Age and Aging, 20,439-441.

Buono, M. J., and N. T. Sjoholm. (1988), Effect of Physical Training on Peripheral Sweat Production, Journal of Applied Physiology, 65, 811-814.

Buono, M. J. (1986), Freezing Provides a Viable Method for the Prolonged, Stable Storage of Blood Lactate, Canadian Journal of Applied Sport Science, 11,80-81.

Buono, M. J. and P. E. Faucher. (1985), Intraerythrocyte and Plasma Osmolality during Graded Exercise in Humans, Journal of Applied Physiology, 58,1069-1072.